We investigate the relations between neurocognitive profiles and the brain using magnetic resonance imaging (MRI) techniques with both healthy and clinical samples. Recent studies have investigated structural volumes of brain regions, grey and white matter concentrations (VBM, voxel-based morphometry; DTI, diffusion tensor imaging), functional activation (fMRI BOLD response) during cognitive tasks, and functional connectivity across the brain (PLS, partial least squares analyses). Primary domains of interest are memory and medial-temporal lobe function. MRI scanning is performed via collaborations with imaging centres at Toronto Western Hospital (TWH), St. Joseph’s Healthcare Hamilton (SJHH), and the Centre for Addiction and Mental Health (CAMH). Through Ryerson’s Institute for Stress and Wellbeing Research, we also plan to incorporate use of fNIRS (functional near-infrared spectroscopy). To investigate spatial memory and navigation in the MRI scanner we harness virtual-reality paradigms. Samples of interest include both healthy and clinical participants. We also conduct meta-analyses of functional brain activation using activation likelihood estimation (ALE).